Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQPZTM)

DTT Name	Sodium/phosphate cotransporter 2B (SLC34A2)
Synonyms	Solute carrier family 34 member 2; Sodium-phosphate transport protein 2B; Sodium-dependent phosphate transport protein 2B; NaPi3b; NaPi-2b; Na(+)/Pi cotransporter 2B; Na(+)-dependent phosphate cotransporter 2B
Gene Name	SLC34A2
DTT Type	Clinical trial target	[1]
BioChemical Class	Phosphate:sodium symporter
UniProt ID	NPT2B_HUMAN
TTD ID	T98798
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLI DEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSS AFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRA AIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHY LEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVK IWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLP DLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAI LVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNA LRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLI PLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSL KPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVK APETFDNITISREAQGEVPASDSKTECTAL
Function	It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. May be involved in actively transporting phosphate into cells via Na(+) cotransport.
KEGG Pathway	Parathyroid hormone synthesis, secretion and action (hsa04928 ) Mineral absorption (hsa04978 )
Reactome Pathway	Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) (R-HSA-5619045 ) Surfactant metabolism (R-HSA-5683826 ) Defective SLC34A2 causes PALM (R-HSA-5687583 ) Type II Na+/Pi cotransporters (R-HSA-427589 )
BioCyc Pathway	MetaCyc:ENSG00000157765-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DTT

2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Upifitamab rilsodotin	DMCWLHD	Ovarian cancer	2C73	Phase 3	[2]
XMT-1592	DMU6TG7	Non-small-cell lung cancer	2C25.Y	Phase 1/2	[3]
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The Drug Transporter (DTP) Role of This DTT

DTT DTP Name

Sodium-dependent phosphate transport protein 2B (SLC34A2) DTP Info

Gene Name

SLC34A2

1 Approved Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium phosphate dibasic/sodium phosphate monobasic	DMKY27B	Multiple sclerosis	8A40	Approved	[4]
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References

1	Solute carrier family 34 member 2 overexpression contributes to tumor growth and poor patient survival in colorectal cancer. Biomed Pharmacother. 2018 Mar;99:645-654.
2	Clinical pipeline report, company report or official report of Mersana Therapeutics
3	Clinical pipeline report, company report or official report of Mersana Therapeutics.
4	Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50.