Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQRVC9)

DTT Name	Large ribosomal subunit protein eL15 (RPL15)
Synonyms	TCBAP0781; EC45; 60S ribosomal protein L15
Gene Name	RPL15
DTT Type	Literature-reported target	[1]
UniProt ID	RL15_HUMAN
TTD ID	T73230
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYV IYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYW VGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKF HHTIGGSRRAAWRRRNTLQLHRYR
Function	Up-regulated in gastric cancer tissues. Also highly expressed in gastric cancer cell lines AGS, MKN45, MKN28, SGC7901 and KATOIII.
KEGG Pathway	Ribosome (hsa03010 ) Coronavirus disease - COVID-19 (hsa05171 )
Reactome Pathway	Peptide chain elongation (R-HSA-156902 ) SRP-dependent cotranslational protein targeting to membrane (R-HSA-1799339 ) Viral mRNA Translation (R-HSA-192823 ) Selenocysteine synthesis (R-HSA-2408557 ) Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226 ) Formation of a pool of free 40S subunits (R-HSA-72689 ) GTP hydrolysis and joining of the 60S ribosomal subunit (R-HSA-72706 ) Eukaryotic Translation Termination (R-HSA-72764 ) Regulation of expression of SLITs and ROBOs (R-HSA-9010553 ) Response of EIF2AK4 (GCN2) to amino acid deficiency (R-HSA-9633012 ) Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (R-HSA-975956 ) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (R-HSA-975957 ) L13a-mediated translational silencing of Ceruloplasmin expression (R-HSA-156827 )

References

1	Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer. BMC Cancer. 2006 Apr 11;6:91.