Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQWUPT)

• DTT Name: Thyroid hormone receptor (THR)
• Gene Name: NO-GeName
• DTT Type: Clinical trial target; [1]
• Related Disease:
  Dementia [ICD-11: 6D80-6D8Z]
  Dyslipidemia [ICD-11: 5C80-5C81]
  Schizophrenia [ICD-11: 6A20]
  Solid tumour/cancer [ICD-11: 2A00-2F9Z]
• UniProt ID: NOUNIPROTAC
• TTD ID: T43760

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
B7-2/GM-CSF	DM0LKHV	Dementia	6D80-6D86	Phase 1	[2]

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KB-5359	DMM7S3V	Lipid metabolism disorder	5C52.Z	Terminated	[3]

4 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GC-14	DMYMGBA	Discovery agent	N.A.	Investigative	[4]
Neplanocin A	DMXULGK	Discovery agent	N.A.	Investigative	[4]
NH-3	DMYAB79	Discovery agent	N.A.	Investigative	[4]
NH-4	DMSUZFO	Discovery agent	N.A.	Investigative	[4]

References

• [1] Diiodothyropropionic Acid (DITPA) in the Treatment of MCT8 Deficiency
• [2] Sobetirome: a case history of bench-to-clinic drug discovery and development. Heart Fail Rev. 2010 Mar;15(2):177-82.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [4] Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol. 2002 Dec;83(1-5):59-73.