Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTRAMF0)

• DTT Name: Plasmodium Cytochrome B (Malaria MT-CYB)
• Synonyms: MT-CYB; Cyb
• Gene Name: Malaria MT-CYB
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Cytochrome b family
• UniProt ID: CYB_PLAFA
• TTD ID: T53489
• Sequence:
  MNFYSINLVKAHLINYPCPLNINFLWNYGFLLGIIFFIQIITGVFLASRYTPDVSYAYYS
  IQHILRELWSGWCFRYMHATGASLVFLLTYLHILRGLNYSYMYLPLSWISGLILFMIFIV
  TAFVGYVLPWGQMSYWGATVITNLLSSIPVAVIWICGGYTVSDPTIKRFFVLHFILPFIG
  LCIVFIHIFFLHLHGSTNPLGYDTALKIPFYPNLLSLDVKGFNNVIILFLIQSLFGIIPL
  SHPDNAIVVNTYVTPSQIVPEWYFLPFYAMLKTVPSKPAGLVIVLLSLQLLFLLAEQRSL
  TTIIQFKMIFGARDYSVPIIWFMCAFYALLWIGCQLPQDIFILYGRLFIVLFFCSGLFVL
  VHYRRTHYDYSSQANI
• Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
• KEGG Pathway:
  Oxidative phosphorylation (pfa00190)
  Metabolic pathways (pfa01100)

Molecular Interaction Atlas (MIA) of This DTT

7 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-NONYL-4-HYDROXYQUINOLINE N-OXIDE	DMQWR69	Discovery agent	N.A.	Investigative	[2]
5-heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione	DM49F6Z	Discovery agent	N.A.	Investigative	[2]
5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole	DM74JL8	Discovery agent	N.A.	Investigative	[2]
B-2-Octylglucoside	DMEGX8H	Discovery agent	N.A.	Investigative	[1]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[1]
FAMOXADONE	DMJYNMC	Discovery agent	N.A.	Investigative	[2]
UBIQUINONE-2	DMLUP30	Discovery agent	N.A.	Investigative	[2]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.