Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTRBUYN)

• DTT Name: Ribonuclease (RNase)
• Gene Name: RNase
• DTT Type: Clinical trial target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T50461

Molecular Interaction Atlas (MIA) of This DTT

3 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NTO-1151	DMRYLBW	Cervical cancer	2C77.0	Phase 2	[1]
Ranpirnase	DMM15RI	Lung cancer	2C25.0	Phase 2	[2]
MazF gene therapy	DMSZ8HT	Human immunodeficiency virus-1 infection	1C62	Phase 1	[3]

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AS-1406	DMRYQBE	Solid tumour/cancer	2A00-2F9Z	Terminated	[4]

References

• [1] Clinical pipeline report, company report or official report of Nanotherapeutics.
• [2] Ranpirnase (Onconase), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy.Expert Opin Biol Ther. 2008 Jun;8(6):813-27.
• [3] Clinical pipeline report, company report or official report of Takara Bio.
• [4] WO patent application no. 2005,0657,17, Liquid formulations of antibody conjugates.