Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTRG4QN)

DTT Name	Activin receptor type II (ACVR2)
Gene Name	ACVR2
DTT Type	Clinical trial target	[1]
UniProt ID	AVR2A_HUMAN ; AVR2B_HUMAN
TTD ID	T13209
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
KEGG Pathway	Cytokine-cytokine receptor interaction (hsa04060 ) TGF-beta signaling pathway (hsa04350 ) Signaling pathways regulating pluripotency of stem cells (hsa04550 ) Fluid shear stress and atherosclerosis (hsa05418 )
Reactome Pathway	Regulation of signaling by NODAL (R-HSA-1433617 ) Signaling by Activin (R-HSA-1502540 ) Signaling by BMP (R-HSA-201451 ) Signaling by NODAL (R-HSA-1181150 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bimagrumab	DMH7Q4E	Type 2 diabetes	5A11	Phase 2	[1]
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References

1	Effects of bimagrumab, an activin receptor type II inhibitor, on pituitary neurohormonal axes. Clin Endocrinol (Oxf). 2018 Jun;88(6):908-919.