Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTRGZX3)

DTT Name Gap junction beta-2 protein (Cx26)
Synonyms Connexin-26
Gene Name GJB2
DTT Type
Literature-reported target
 [1]
BioChemical Class
Gap junction-forming connexin
UniProt ID
CXB2_HUMAN
TTD ID
T88947
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGC
KNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRHEKKRKFIKGEIKSEFKDIEE
IKTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDC
FVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCSGKSKKPV
Function
Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore. Structural component of gap junctions.
Reactome Pathway
Transport of connexins along the secretory pathway (R-HSA-190827 )
Gap junction assembly (R-HSA-190861 )
Transport of connexons to the plasma membrane (R-HSA-190872 )
Oligomerization of connexins into connexons (R-HSA-190704 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
octanol DMBGHPE Discovery agent N.A. Investigative [1]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 716).