Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTRU01G)

DTT Name	N-glycosylase/DNA lyase (OGG1)
Synonyms	OGH1; MUTM; MMH
Gene Name	OGG1
DTT Type	Literature-reported target	[1]
BioChemical Class	Type-1 OGG1 family
UniProt ID	OGG1_HUMAN
TTD ID	T92189
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLA DQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHF QEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHG FPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKAL CILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELG NFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
Function	DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
KEGG Pathway	Base excision repair (hsa03410 )
Reactome Pathway	Cleavage of the damaged pyrimidine (R-HSA-110329 ) Recognition and association of DNA glycosylase with site containing an affected purine (R-HSA-110330 ) Cleavage of the damaged purine (R-HSA-110331 ) Displacement of DNA glycosylase by APEX1 (R-HSA-110357 ) APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (R-HSA-5649702 ) Defective OGG1 Substrate Binding (R-HSA-9656255 ) Defective OGG1 Substrate Processing (R-HSA-9656256 ) Defective OGG1 Localization (R-HSA-9657050 ) Recognition and association of DNA glycosylase with site containing an affected pyrimidine (R-HSA-110328 )

References

1	The reaction mechanism of DNA glycosylase/AP lyases at abasic sites. Biochemistry. 2001 Jan 16;40(2):561-8.