Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTS0EZJ)

• DTT Name: Hydroxymethylglutaryl-CoA synthase 2 (HMGCS2)
• Synonyms: HMGCS2; HMG-CoAsynthase; 3-hydroxy-3-methylglutaryl coenzyme A synthase 2
• Gene Name: HMGCS2
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Acyltransferase
• UniProt ID: HMCS2_HUMAN
• TTD ID: T89082
• EC Number: EC 2.3.3.10
• Sequence:
  MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALE
  VYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLP
  WDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWM
  ESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYD
  FYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIF
  HTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKAS
  QDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASF
  FSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPG
  DTNSLFPGTWYLERVDEQHRRKYARRPV
• Function: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
• KEGG Pathway:
  Synthesis and degradation of ketone bodies (hsa00072)
  Valine, leucine and isoleucine degradation (hsa00280)
  Butanoate metabolism (hsa00650)
  Terpenoid backbone biosynthesis (hsa00900)
  Metabolic pathways (hsa01100)
  Biosynthesis of antibiotics (hsa01130)
  PPAR signaling pathway (hsa03320)
• Reactome Pathway: PPARA activates gene expression (R-HSA-1989781)
• BioCyc Pathway: MetaCyc:HS05836-MON

Molecular Interaction Atlas (MIA) of This DTT

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3-Sulfinoalanine	DMILTRN	N. A.	N. A.	Investigative	[1]
Acetoacetyl-Coenzyme A	DM3HYU8	Discovery agent	N.A.	Investigative	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.