Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTS41ER)

• DTT Name: HUMAN cyclophilin A (CYPA)
• Synonyms: PPIA; Cyclophilin A; CyPA
• Gene Name: PPIA
• Related Disease: Hepatitis virus infection [ICD-11: 1E50-1E51]
• BioChemical Class: Cis-trans-isomerases
• UniProt ID: PPIA_HUMAN
• TTD ID: T98092
• EC Number: EC 5.2.1.8
• Sequence:
  MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGF
  MCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTE
  WLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
• Function: Ppiases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
• Reactome Pathway:
  Uncoating of the HIV Virion (R-HSA-162585)
  Budding and maturation of HIV virion (R-HSA-162588)
  Integration of provirus (R-HSA-162592)
  Early Phase of HIV Life Cycle (R-HSA-162594)
  Minus-strand DNA synthesis (R-HSA-164516)
  Plus-strand DNA synthesis (R-HSA-164525)
  Binding and entry of HIV virion (R-HSA-173107)
  Assembly Of The HIV Virion (R-HSA-175474)
  APOBEC3G mediated resistance to HIV-1 infection (R-HSA-180689)
  Calcineurin activates NFAT (R-HSA-2025928)
  Basigin interactions (R-HSA-210991)
  Neutrophil degranulation (R-HSA-6798695)
  Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (R-HSA-8950505)
  Platelet degranulation (R-HSA-114608)

Molecular Interaction Atlas (MIA) of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alisporivir	DMWMIRL	Hepatitis C virus infection	1E51.1	Investigative	[1], [2]

References

• [1] Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150.
• [2] Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.