| DTT Name |
HUMAN cathepsin L (CTSL)
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| Synonyms |
Major excreted protein; MEP; Cathepsin L1; CTSL1 |
| Gene Name |
CTSL
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| BioChemical Class |
Peptidase
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| UniProt ID |
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| TTD ID |
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| 3D Structure |
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| EC Number |
EC 3.4.22.15
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| Sequence |
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| Function |
Important for the overall degradation of proteins in lysosomes. |
| KEGG Pathway |
- Autophagy - animal (hsa04140 )
- Lysosome (hsa04142 )
- Phagosome (hsa04145 )
- Apoptosis (hsa04210 )
- Antigen processing and presentation (hsa04612 )
- Proteoglycans in cancer (hsa05205 )
- Rheumatoid arthritis (hsa05323 )
- Fluid shear stress and atherosclerosis (hsa05418 )
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| Reactome Pathway |
- Collagen degradation (R-HSA-1442490 )
- Degradation of the extracellular matrix (R-HSA-1474228 )
- Trafficking and processing of endosomal TLR (R-HSA-1679131 )
- Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090 )
- MHC class II antigen presentation (R-HSA-2132295 )
- RUNX1 regulates transcription of genes involved in differentiation of keratinocytes (R-HSA-8939242 )
- Attachment and Entry (R-HSA-9678110 )
- Attachment and Entry (R-HSA-9694614 )
- Endosomal/Vacuolar pathway (R-HSA-1236977 )
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