Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTSJIRP)

DTT Name	Connexin 32 messenger RNA (GJB1 mRNA)
Synonyms	Gap junction beta-1 protein (mRNA); GAP junction 28 kDa liver protein (mRNA); CX32 (mRNA)
Gene Name	GJB1
DTT Type	Literature-reported target	[1]
BioChemical Class	mRNA target
UniProt ID	CXB1_HUMAN
TTD ID	T27984
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGC NSVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLEGHGDPLHLEEV KRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLVKCDVYPCPNTVDCF VSRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRACARRAQRRSNPPSRKGSGFGHRLS PEYKQNEINKLLSEQDGSLKDILRRSPGTGAGLAEKSDRCSAC
Function	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Reactome Pathway	Transport of connexins along the secretory pathway (R-HSA-190827 ) Gap junction assembly (R-HSA-190861 ) Oligomerization of connexins into connexons (R-HSA-190704 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sc-43076	DMVZ9Q0	Discovery agent	N.A.	Investigative	[1]
Sc-43077	DMYDS5Z	Discovery agent	N.A.	Investigative	[1]
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References

1	Connexin Antibodies. Report from santa cruz biotechnology, inc. Santa cruz biotechnology. 2009.