Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTSM4BA)

DTT Name	RNA-binding protein Musashi-1 (MSI1)
Synonyms	RNA-binding protein Musashi homolog 1; Musashi-1
Gene Name	MSI1
DTT Type	Literature-reported target	[1]
UniProt ID	MSI1H_HUMAN
TTD ID	T21715
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	METDAPQPGLASPDSPHDPCKMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRS RGFGFVTFMDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNT TVEDVKQYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVE CKKAQPKEVMSPTGSARGRSRVMPYGMDAFMLGIGMLGYPGFQATTYASRSYTGLAPGYT YQFPEFRVERTPLPSAPVLPELTAIPLTAYGPMAAAAAAAAVVRGTGSHPWTMAPPPGST PSRTGGFLGTTSPGPMAELYGAANQDSGVSSYISAASPAPSTGFGHSLGGPLIATAFTNG YH
Function	Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system. RNA binding protein that regulates the expression of target mRNAs at the translation level.
KEGG Pathway	mRNA surveillance pathway (hsa03015 )
Reactome Pathway	Regulation of expression of SLITs and ROBOs (R-HSA-9010553 )

References

1	The RNA-binding protein Musashi 1 stabilizes the oncotachykinin 1 mRNA in breast cancer cells to promote cell growth. FASEB J. 2016 Jan;30(1):149-59.