Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTSM78N)

• DTT Name: Platelet-derived growth factor A (PDGFA)
• Synonyms: Platelet-derived growth factor subunit A; Platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor A chain; Platelet derived growth factor; PDGF1; PDGF-1; PDGF subunit A; PDGF; C-SIS oncogene
• Gene Name: PDGFA
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Growth factor
• UniProt ID: PDGFA_HUMAN
• TTD ID: T06869
• Sequence:
  MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLD
  TSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIW
  PPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACA
  TTSLNPDYREEDTGRPRESGKKRKRKRLKPT
• Function: Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis.
• KEGG Pathway:
  EGFR tyrosine kinase inhibitor resistance (hsa01521)
  MAPK signaling pathway (hsa04010)
  Ras signaling pathway (hsa04014)
  Rap1 signaling pathway (hsa04015)
  Calcium signaling pathway (hsa04020)
  Phospholipase D signaling pathway (hsa04072)
  PI3K-Akt signaling pathway (hsa04151)
  Focal adhesion (hsa04510)
  Gap junction (hsa04540)
  JAK-STAT signaling pathway (hsa04630)
  Regulation of actin cytoskeleton (hsa04810)
  Pathways in cancer (hsa05200)
  Transcriptional misregulation in cancer (hsa05202)
  MicroRNAs in cancer (hsa05206)
  Glioma (hsa05214)
  Prostate cancer (hsa05215)
  Melanoma (hsa05218)
  Choline metabolism in cancer (hsa05231)
  Fluid shear stress and atherosclerosis (hsa05418)
• Reactome Pathway:
  PIP3 activates AKT signaling (R-HSA-1257604)
  Downstream signal transduction (R-HSA-186763)
  Signaling by PDGF (R-HSA-186797)
  Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)
  Non-integrin membrane-ECM interactions (R-HSA-3000171)
  RAF/MAP kinase cascade (R-HSA-5673001)
  PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (R-HSA-6811558)
  Platelet degranulation (R-HSA-114608)

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Squalamine	DM3PS2E	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)