Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTSMT9W)

DTT Name	Sarcoglycan gamma (SGCG)
Synonyms	SGCG; Gammasarcoglycan; GammaSG; 35DAG; 35 kDa dystrophinassociated glycoprotein
Gene Name	SGCG
DTT Type	Literature-reported target	[1]
BioChemical Class	Sarcoglycan
UniProt ID	SGCG_HUMAN
TTD ID	T16401
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MVREQYTTATEGICIERPENQYVYKIGIYGWRKRCLYLFVLLLLIILVVNLALTIWILKV MWFSPAGMGHLCVTKDGLRLEGESEFLFPLYAKEIHSRVDSSLLLQSTQNVTVNARNSEG EVTGRLKVGPKMVEVQNQQFQINSNDGKPLFTVDEKEVVVGTDKLRVTGPEGALFEHSVE TPLVRADPFQDLRLESPTRSLSMDAPRGVHIQAHAGKIEALSQMDILFHSSDGMLVLDAE TVCLPKLVQGTWGPSGSSQSLYEICVCPDGKLYLSVAGVSTTCQEHNHICL
Function	Component of the sarcoglycan complex, a subcomplexof the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
KEGG Pathway	Hypertrophic cardiomyopathy (hsa05410 ) Arrhythmogenic right ventricular cardiomyopathy (hsa05412 ) Dilated cardiomyopathy (hsa05414 ) Viral myocarditis (hsa05416 )

References

1	Gamma-sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin. J Cell Biol. 1998 Sep 7;142(5):1279-87.