General Information of Drug Therapeutic Target (DTT) (ID: TTSTNJR)

DTT Name COPS5 messenger RNA (COPS5 mRNA)
Synonyms Signalosome subunit 5 (mRNA); SGN5 (mRNA); Jun activation domain-binding protein 1 (mRNA); JAB1 (mRNA); CSN5 (mRNA); COP9 signalosome complex subunit 5 (mRNA)
Gene Name COPS5
DTT Type
Literature-reported target
[1]
BioChemical Class
mRNA target
UniProt ID
CSN5_HUMAN
TTD ID
T60004
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 3.4.-.-
Sequence
MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISAL
ALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAY
IENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGK
VNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLEL
LWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKL
AKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS
Function
The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
Reactome Pathway
Formation of TC-NER Pre-Incision Complex (R-HSA-6781823 )
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825 )
Neddylation (R-HSA-8951664 )
DNA Damage Recognition in GG-NER (R-HSA-5696394 )

References

1 Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components. BMC Genomics. 2016 Dec 1;17(1):983.