General Information of Drug Therapeutic Target (DTT) (ID: TTSTVM0)

DTT Name High mobility group protein HMGI-C (HMGA2)
Synonyms High mobility group AThook protein 2; High mobility group AT-hook protein 2; HMGIC
Gene Name HMGA2
DTT Type
Literature-reported target
[1]
UniProt ID
HMGA2_HUMAN
TTD ID
T48166
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSP
SKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQEETEETSSQESAEED
Function
Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation. Functions as a transcriptional regulator.
KEGG Pathway
Transcriptional misregulation in cancer (hsa05202 )
MicroRNAs in cancer (hsa05206 )
Reactome Pathway
Formation of Senescence-Associated Heterochromatin Foci (SAHF) (R-HSA-2559584 )

References

1 HMGA2 regulates lung cancer proliferation and metastasis. Thorac Cancer. 2017 Sep;8(5):501-510.