Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTT2CZY)

DTT Name	Retinoschisin (RS1)
Synonyms	X-linked juvenile retinoschisis protein; RS1
Gene Name	RS1
DTT Type	Clinical trial target	[1]
UniProt ID	XLRS1_HUMAN
TTD ID	T54031
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSRKIEGFLLLLLFGYEATLGLSSTEDEGEDPWYQKACKCDCQGGPNALWSAGATSLDCI PECPYHKPLGFESGEVTPDQITCSNPEQYVGWYSSWTANKARLNSQGFGCAWLSKFQDSS QWLQIDLKEIKVISGILTQGRCDIDEWMTKYSVQYRTDERLNWIYYKDQTGNNRVFYGNS DRTSTVQNLLRPPIISRFIRLIPLGWHVRIAIRMELLECVSKCA
Function	May be active in cell adhesion processes during retinal development.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIIB-087	DMR8EPF	X-linked retinoschisis	9B73.11	Phase 1/2	[2]
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References

1	The X-linked juvenile retinoschisis protein retinoschisin is a novel regulator of mitogen-activated protein kinase signalling and apoptosis in the ... J Cell Mol Med. 2017 Apr;21(4):768-780.
2	ClinicalTrials.gov (NCT02416622) Safety and Efficacy of rAAV-hRS1 in Patients With X-linked Retinoschisis (XLRS). U.S. National Institutes of Health.