Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTT2F9E)

DTT Name	Ciliary neurotrophic factor receptor alpha (CNTFR)
Synonyms	Ciliary neurotrophic factor receptor subunit alpha; CNTFR-alpha; CNTFR alpha; CNTF receptor subunit alpha
Gene Name	CNTFR
DTT Type	Clinical trial target	[1]
BioChemical Class	Cytokine receptor
UniProt ID	CNTFR_HUMAN
TTD ID	T61033
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL AAAAATASSLLI
Function	The alpha subunit provides the receptor specificity. Binds to CNTF.
KEGG Pathway	Cytokine-cytokine receptor interaction (hsa04060 ) Jak-STAT signaling pathway (hsa04630 )
Reactome Pathway	IL-6-type cytokine receptor ligand interactions (R-HSA-6788467 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NT-501	DM4H78P	Ocular inflammation	9C61.24	Phase 2/3	[1]
PegCNTF	DMW7VGZ	Obesity	5B81	Phase 1	[2]
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References

1	Clinical pipeline report, company report or official report of Neurotech.
2	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.