Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTT48SQ)

DTT Name	Voltage-dependent anion-selective channel 3 (VDAC3)
Synonyms	hVDAC3; VDAC3; VDAC-3; Outer mitochondrial membrane protein porin 3
Gene Name	VDAC3
DTT Type	Clinical trial target	[1]
BioChemical Class	Eukaryotic mitochondrial porin
UniProt ID	VDAC3_HUMAN
TTD ID	T64774
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLET KYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKR DCFSVGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQL HTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNA SLIGLGYTQTLRPGVKLTLSALIDGKNFSAGGHKVGLGFELEA
Function	Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
KEGG Pathway	Calcium signaling pathway (hsa04020 ) cGMP-PKG signaling pathway (hsa04022 ) Parkinson's disease (hsa05012 ) Huntington's disease (hsa05016 ) Hepatitis B (hsa05161 ) HTLV-I infection (hsa05166 ) Viral carcinogenesis (hsa05203 )
Reactome Pathway	Mitochondrial calcium ion transport (R-HSA-8949215 ) Ub-specific processing proteases (R-HSA-5689880 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PRLX93936	DM8J5H1	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
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References

1	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.