General Information of Drug Therapeutic Target (DTT) (ID: TTT54CI)

DTT Name Folate receptor beta (FOLR2)
Synonyms Placental folate-binding protein; Folate receptor, fetal/placental; Folate receptor type-beta; Folate receptor 2; FR-beta; FOLR2
Gene Name FOLR2
DTT Type
Literature-reported target
[1]
BioChemical Class
Folate receptor
UniProt ID
FOLR2_HUMAN
TTD ID
T82297
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACC
TASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRK
ERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPA
ALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGG
LLLSLALMLQLWLLG
Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
KEGG Pathway
Antifolate resistance (hsa01523 )
Endocytosis (hsa04144 )
Reactome Pathway
Metabolism of folate and pterines (R-HSA-196757 )
Post-translational modification (R-HSA-163125 )

References

1 Strategy for the treatment of acute myelogenous leukemia based on folate receptor beta-targeted liposomal doxorubicin combined with receptor induct... Blood. 2002 Jul 15;100(2):594-602.