Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTTCRU2)

DTT Name Bacterial Fimbrin D-mannose adhesin (Bact FimH)
Synonyms fimH; b4320; Type 1 fimbrin D-mannose specific adhesin; Protein FimH; JW4283
Gene Name Bact FimH
DTT Type
Clinical trial target
 [1]
UniProt ID
FIMH_ECOLI
TTD ID
T46526
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLS
TQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRT
DKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTG
GCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQ
GVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ
Function
Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed. Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae).
BioCyc Pathway
EcoCyc:EG10315-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
EB8018 DM753H8 Crohn disease DD70 Phase 2 [2]
GSK3882347 DM1DU20 Urinary tract infection GC08 Phase 1 [3]
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188 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alkyl mannoside derivative 1 DMW57UB Crohn disease DD70 Patented [1]
Alkyl mannoside derivative 10 DMHD51F Crohn disease DD70 Patented [1]
Alkyl mannoside derivative 11 DMMNZ2U Crohn disease DD70 Patented [1]
Alkyl mannoside derivative 12 DMX1OZF Crohn disease DD70 Patented [1]
Alkyl mannoside derivative 2 DMNQUKP Crohn disease DD70 Patented [1]
Alkyl mannoside derivative 3 DML2B58 Crohn disease DD70 Patented [1]
Alkyl mannoside derivative 4 DMZR71O Crohn disease DD70 Patented [1]
Alkyl mannoside derivative 5 DM04ZJ2 Crohn disease DD70 Patented [1]
Alkyl mannoside derivative 6 DMCIV32 Crohn disease DD70 Patented [1]
Alkyl mannoside derivative 7 DMBLSH1 Crohn disease DD70 Patented [1]
Alkyl mannoside derivative 8 DMZP1JT Crohn disease DD70 Patented [1]
Alkyl mannoside derivative 9 DMV1QUX Crohn disease DD70 Patented [1]
Aryl mannoside derivative 1 DM1TV6F Crohn disease DD70 Patented [1]
Aryl mannoside derivative 10 DM251GL Crohn disease DD70 Patented [1]
Aryl mannoside derivative 11 DMRVIPL Crohn disease DD70 Patented [1]
Aryl mannoside derivative 12 DMOG8XT Crohn disease DD70 Patented [1]
Aryl mannoside derivative 13 DM2W7JE Crohn disease DD70 Patented [1]
Aryl mannoside derivative 14 DMR648Z Crohn disease DD70 Patented [1]
Aryl mannoside derivative 15 DMQS8CF Crohn disease DD70 Patented [1]
Aryl mannoside derivative 16 DMP6QEC Crohn disease DD70 Patented [1]
Aryl mannoside derivative 17 DM0FSPQ Crohn disease DD70 Patented [1]
Aryl mannoside derivative 18 DM0YUBR Crohn disease DD70 Patented [1]
Aryl mannoside derivative 19 DM6K29H Crohn disease DD70 Patented [1]
Aryl mannoside derivative 2 DM4S2U5 Crohn disease DD70 Patented [1]
Aryl mannoside derivative 20 DMZ2RV3 Crohn disease DD70 Patented [1]
Aryl mannoside derivative 21 DMJBY68 Crohn disease DD70 Patented [1]
Aryl mannoside derivative 22 DMJFDNB Crohn disease DD70 Patented [1]
Aryl mannoside derivative 23 DMWUNRV Crohn disease DD70 Patented [1]
Aryl mannoside derivative 3 DMF5XU8 Crohn disease DD70 Patented [1]
Aryl mannoside derivative 4 DMO19Y6 Crohn disease DD70 Patented [1]
Aryl mannoside derivative 5 DMMC31R Crohn disease DD70 Patented [1]
Aryl mannoside derivative 6 DM5MIEC Crohn disease DD70 Patented [1]
Aryl mannoside derivative 7 DM9YS40 Crohn disease DD70 Patented [1]
Aryl mannoside derivative 8 DMK6PFQ Crohn disease DD70 Patented [1]
Aryl mannoside derivative 9 DMNSK7U Crohn disease DD70 Patented [1]
Beta-cyclodextrin conjugate derivative 1 DMZKTHL Crohn disease DD70 Patented [1]
Beta-cyclodextrin conjugate derivative 2 DM9W1FO Crohn disease DD70 Patented [1]
Beta-cyclodextrin conjugate derivative 3 DMQJF4P Crohn disease DD70 Patented [1]
Beta-cyclodextrin conjugate derivative 4 DMO9RE8 Crohn disease DD70 Patented [1]
Beta-cyclodextrin conjugate derivative 5 DML2B7G Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 1 DMX6YGS Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 10 DMPF37N Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 11 DMKES0G Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 12 DM5T29W Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 13 DM1Y8OM Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 14 DM4C5QY Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 15 DMKXT7H Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 16 DMP9742 Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 17 DMIXV6G Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 18 DMHOPE0 Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 19 DME8DQ0 Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 2 DMMB60X Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 20 DMNC5S0 Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 21 DMGSLHN Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 22 DMYLVB3 Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 23 DM2YVGH Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 24 DMF5TB4 Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 25 DMRM3E9 Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 26 DMYXLCJ Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 27 DMTDPHY Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 28 DMSNMZ2 Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 29 DMCLTY3 Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 3 DMAITK3 Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 30 DMPLAWQ Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 31 DMMPJ3E Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 4 DMVF63N Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 5 DMRS1WG Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 6 DMEWA7U Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 7 DMD7053 Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 8 DMWF2VG Crohn disease DD70 Patented [1]
Biaryl mannoside derivative 9 DM1Q7AL Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 1 DMS5UFX Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 10 DMITLPW Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 11 DMZF5XI Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 12 DMU0YST Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 13 DM83LTH Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 14 DMMRTWG Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 15 DM97BIQ Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 16 DMECZVG Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 17 DM7L8T5 Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 18 DM2GZ5Y Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 19 DMGA0R6 Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 2 DMQB4DR Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 20 DMDIYJ1 Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 21 DMTR6BX Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 22 DMQGFKY Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 23 DMC8OVU Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 24 DMLUZ3K Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 25 DMBWQ8L Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 26 DM5Q4T2 Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 27 DMWQ6FJ Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 28 DMMOTWK Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 29 DM9H0Q3 Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 3 DMOKJEP Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 30 DM81RIY Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 4 DM0VR23 Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 5 DMOS03R Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 6 DM93VEB Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 7 DM46NRV Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 8 DMZCWM5 Crohn disease DD70 Patented [1]
Biphenyl mannoside derivative 9 DMP52HJ Crohn disease DD70 Patented [1]
C-linked disaccharide biphenyl mannoside derivative 1 DMV6H95 Crohn disease DD70 Patented [1]
C-linked disaccharide biphenyl mannoside derivative 2 DMJT1WG Crohn disease DD70 Patented [1]
C-linked disaccharide biphenyl mannoside derivative 3 DMY10T2 Crohn disease DD70 Patented [1]
C-linked disaccharide biphenyl mannoside derivative 4 DMRLE65 Crohn disease DD70 Patented [1]
C-linked disaccharide biphenyl mannoside derivative 5 DMUG7E9 Crohn disease DD70 Patented [1]
C-linked disaccharide biphenyl mannoside derivative 6 DMUILMD Crohn disease DD70 Patented [1]
Mannoside derivative 1 DMIE7U3 Crohn disease DD70 Patented [1]
Mannoside derivative 10 DMZYRHN Crohn disease DD70 Patented [1]
Mannoside derivative 11 DM8I051 Crohn disease DD70 Patented [1]
Mannoside derivative 12 DM4QUY0 Crohn disease DD70 Patented [1]
Mannoside derivative 13 DM0U7P9 Crohn disease DD70 Patented [1]
Mannoside derivative 2 DMFEQD2 Crohn disease DD70 Patented [1]
Mannoside derivative 3 DMPF2UG Crohn disease DD70 Patented [1]
Mannoside derivative 4 DMZBY73 Crohn disease DD70 Patented [1]
Mannoside derivative 5 DMMXNY8 Crohn disease DD70 Patented [1]
Mannoside derivative 6 DMCM3NW Crohn disease DD70 Patented [1]
Mannoside derivative 7 DMOUT1F Crohn disease DD70 Patented [1]
Mannoside derivative 8 DMKTJAH Crohn disease DD70 Patented [1]
Mannoside derivative 9 DMIKZXD Crohn disease DD70 Patented [1]
PMID26651364-Compound-105 DMOJVK6 Crohn disease DD70 Patented [1]
PMID26651364-Compound-106 DMQZJDF Crohn disease DD70 Patented [1]
PMID26651364-Compound-107 DMMZ1WL Crohn disease DD70 Patented [1]
PMID26651364-Compound-108 DMA7D3K Crohn disease DD70 Patented [1]
PMID26651364-Compound-109 DM01IWV Crohn disease DD70 Patented [1]
PMID26651364-Compound-10a DMTPBNY Crohn disease DD70 Patented [1]
PMID26651364-Compound-10b DM16ANH Crohn disease DD70 Patented [1]
PMID26651364-Compound-10c DMCRNWA Crohn disease DD70 Patented [1]
PMID26651364-Compound-10d DMGIV3C Crohn disease DD70 Patented [1]
PMID26651364-Compound-110 DMPA3IX Crohn disease DD70 Patented [1]
PMID26651364-Compound-111 DMY9R58 Crohn disease DD70 Patented [1]
PMID26651364-Compound-112 DM1LIRP Crohn disease DD70 Patented [1]
PMID26651364-Compound-113 DM6OQKM Crohn disease DD70 Patented [1]
PMID26651364-Compound-114 DM5GHJA Crohn disease DD70 Patented [1]
PMID26651364-Compound-115 DMHIA26 Crohn disease DD70 Patented [1]
PMID26651364-Compound-116 DMJ3201 Crohn disease DD70 Patented [1]
PMID26651364-Compound-117a DM6LXHS Crohn disease DD70 Patented [1]
PMID26651364-Compound-117b DMUQSM1 Crohn disease DD70 Patented [1]
PMID26651364-Compound-118 DM6ZRV4 Crohn disease DD70 Patented [1]
PMID26651364-Compound-119 DMONAZI Crohn disease DD70 Patented [1]
PMID26651364-Compound-11b DMGBFK3 Crohn disease DD70 Patented [1]
PMID26651364-Compound-11c DM76WBP Crohn disease DD70 Patented [1]
PMID26651364-Compound-120 DMZTBEQ Crohn disease DD70 Patented [1]
PMID26651364-Compound-121 DM4ZG0Q Crohn disease DD70 Patented [1]
PMID26651364-Compound-122 DMVFTIL Crohn disease DD70 Patented [1]
PMID26651364-Compound-123 DMR0E5W Crohn disease DD70 Patented [1]
PMID26651364-Compound-124 DM6VER5 Crohn disease DD70 Patented [1]
PMID26651364-Compound-125 DMINUDB Crohn disease DD70 Patented [1]
PMID26651364-Compound-126a DMSTKH6 Crohn disease DD70 Patented [1]
PMID26651364-Compound-126b DM2I1QZ Crohn disease DD70 Patented [1]
PMID26651364-Compound-126c DM80PI1 Crohn disease DD70 Patented [1]
PMID26651364-Compound-127 DMEN8RA Crohn disease DD70 Patented [1]
PMID26651364-Compound-128 DM4W0BX Crohn disease DD70 Patented [1]
PMID26651364-Compound-4 DMY0HP1 Crohn disease DD70 Patented [1]
PMID26651364-Compound-45 DMLBZGO Crohn disease DD70 Patented [1]
PMID26651364-Compound-46 DMQFDU8 Crohn disease DD70 Patented [1]
PMID26651364-Compound-47 DM4S5PB Crohn disease DD70 Patented [1]
PMID26651364-Compound-48 DMHXFGU Crohn disease DD70 Patented [1]
PMID26651364-Compound-49 DMMV5A9 Crohn disease DD70 Patented [1]
PMID26651364-Compound-5 DMH7XL3 Crohn disease DD70 Patented [1]
PMID26651364-Compound-50 DM6GFYR Crohn disease DD70 Patented [1]
PMID26651364-Compound-5a DM01GVE Crohn disease DD70 Patented [1]
PMID26651364-Compound-5b DMLHJ1E Crohn disease DD70 Patented [1]
PMID26651364-Compound-5c DMDQTA2 Crohn disease DD70 Patented [1]
PMID26651364-Compound-5d DMF6Z5I Crohn disease DD70 Patented [1]
PMID26651364-Compound-5e DM9TJR5 Crohn disease DD70 Patented [1]
PMID26651364-Compound-5f DMAZIY6 Crohn disease DD70 Patented [1]
PMID26651364-Compound-5g DMSW0HB Crohn disease DD70 Patented [1]
PMID26651364-Compound-6a DM8HAJ3 Crohn disease DD70 Patented [1]
PMID26651364-Compound-6b DMBINOJ Crohn disease DD70 Patented [1]
PMID26651364-Compound-6c DMPF86L Crohn disease DD70 Patented [1]
PMID26651364-Compound-6d DM9J57W Crohn disease DD70 Patented [1]
PMID26651364-Compound-6e DM4LF0X Crohn disease DD70 Patented [1]
PMID26651364-Compound-7a DMQMBY9 Crohn disease DD70 Patented [1]
PMID26651364-Compound-7b DM3LCIM Crohn disease DD70 Patented [1]
PMID26651364-Compound-7c DMGCUJB Crohn disease DD70 Patented [1]
PMID26651364-Compound-7d DM89VQT Crohn disease DD70 Patented [1]
PMID26651364-Compound-7e DM2SZ0B Crohn disease DD70 Patented [1]
PMID26651364-Compound-8a DM1M3WF Crohn disease DD70 Patented [1]
PMID26651364-Compound-8b DMYVU36 Crohn disease DD70 Patented [1]
PMID26651364-Compound-8c DME7UNT Crohn disease DD70 Patented [1]
PMID26651364-Compound-8d DMSO2F8 Crohn disease DD70 Patented [1]
PMID26651364-Compound-9a DMAXWPS Crohn disease DD70 Patented [1]
PMID26651364-Compound-9b DM6HTU0 Crohn disease DD70 Patented [1]
PMID26651364-Compound-9c DM49V8G Crohn disease DD70 Patented [1]
PMID26651364-Compound-9d DMF0L3E Crohn disease DD70 Patented [1]
PMID26651364-Compound-9e DM9FIKD Crohn disease DD70 Patented [1]
PMID26651364-Compound-9f DMF1MV6 Crohn disease DD70 Patented [1]
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⏷ Show the Full List of 188 Patented Agent(s)
1 Preclinical Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
mAb926 DMNO20J Urinary tract infection GC08 Preclinical [4]
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References

1 Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97.
2 Clinical pipeline report, company report or official report of Enterome Biosciences.
3 Clinical pipeline report, company report or official report of Fimbrion Therapeutics
4 FimH as a scaffold for regulated molecular recognition. J Biol Eng. 2021 Jan 12;15(1):3.