Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTTD730)

DTT Name Mitochondrial citrate transporter (SLC25A1)
Synonyms Tricarboxylate transport protein, mitochondrial; Tricarboxylate carrier protein; Solute carrier family 25 member 1; SLC20A3; Citrate transport protein; CTP
Gene Name SLC25A1
DTT Type
Literature-reported target
 [1]
UniProt ID
TXTP_HUMAN
TTD ID
T06064
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAPRAPRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSH
PPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLD
STRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGT
YQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTP
LDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEV
VKLLNKVWKTD
Function
Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation (Probable).
Reactome Pathway
Fatty acyl-CoA biosynthesis (R-HSA-75105 )
Gluconeogenesis (R-HSA-70263 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
1,2,3-benzenetricarboxylic acid DMXL5R7 Discovery agent N.A. Investigative [1]
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The Drug Transporter (DTP) Role of This DTT

DTT DTP Name Tricarboxylate transport protein (SLC25A1) DTP Info
Gene Name SLC25A1

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1051).