General Information of Drug Therapeutic Target (DTT) (ID: TTTPE1L)

DTT Name HUMAN opioid receptor sigma 1 (OPRS1)
Synonyms
hSigmaR1; Sigma1R; Sigma1-receptor; Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; SRBP; SR31747-binding protein; SR31747 binding protein 1; SR-BP; SIG-1R; Opioid receptor, sigma 1, isoform 1; OPRS1 protein; Aging-associated gene 8 protein; AAG8
Gene Name SIGMAR1
BioChemical Class
GPCR rhodopsin
UniProt ID
SGMR1_HUMAN
TTD ID
T88547
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
Function
Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112. Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane.
KEGG Pathway
Amyotrophic lateral sclerosis (hsa05014 )
Pathways of neurodegeneration - multiple diseases (hsa05022 )
Reactome Pathway
Potential therapeutics for SARS (R-HSA-9679191 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Haloperidol DM96SE0 Delirium Approved [1]
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4 Investigative Agents Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
E-52862 DMLZU09 Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [1]
PB28 DMMNQ1B Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [1]
PD-144418 DMJKH28 Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [1]
RS-PPCC DMN3ZOD Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [1]
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References

1 A SARS-CoV-2 protein interaction map reveals targets for drug repurposing