Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTTWGIX)

• DTT Name: Leukotriene receptor (LTR)
• Synonyms: Human leukotriene receptor
• Gene Name: LTR
• DTT Type: Clinical trial target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T29649

Molecular Interaction Atlas (MIA) of This DTT

4 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ontazolast	DMS8Q7A	Asthma	CA23	Phase 2	[2]
PIRODOMAST	DMC3T2S	Asthma	CA23	Phase 2	[3]
SR-2640	DMFDA4Y	Asthma	CA23	Phase 2	[1]
WF-11605	DM57FHW	Bacterial infection	1A00-1C4Z	Phase 1	[4]

8 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FK-664	DMFGJNW	Cardiac disease	BA00-BE2Z	Discontinued in Phase 2	[5]
SK&F-S-106203	DM2BDAW	Asthma	CA23	Discontinued in Phase 2	[6]
ABT-080	DMTYWE9	Asthma	CA23	Discontinued in Phase 1	[7]
BAY-Y-1015	DM0UEKF	Inflammation	1A00-CA43.1	Discontinued in Phase 1	[8]
NZ-107	DMXJO5F	Asthma	CA23	Discontinued in Phase 1	[9]
SMP-028	DMQSGOD	Asthma	CA23	Discontinued in Phase 1	[10]
ICI-198615	DM0195G	Asthma	CA23	Terminated	[11]
Tipredane	DMGCI6E	Allergy	4A80-4A85	Terminated	[12]

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MAR--99	DMGF7XC	Asthma	CA23	Investigative	[13]

References

• [1] Effect of the leukotriene LTD4/LTE4 antagonist, SR 2640, in ulcerative colitis: an open clinical study. Prostaglandins Leukot Essent Fatty Acids. 1991 Mar;42(3):181-4.
• [2] Effects of progesterone and leukotriene receptor antagonists in experimental models of P-glycoprotein-related resistance. Eur J Med Res. 1997 Apr 21;2(4):159-64.
• [3] Antiallergy activity of Sch 37224, a new inhibitor of leukotriene formation. J Pharmacol Exp Ther. 1988 Dec;247(3):997-1003.
• [4] WF11605, an antagonist of leukotriene B4 produced by a fungus. II. Structure determination. J Antibiot (Tokyo). 1992 May;45(5):704-8.
• [5] US patent application no. 7,175,854, Pharmaceutical preparation comprising an active dispersed on a matrix.
• [6] Pharmacologic and pharmacokinetic profile of SK&F S-106203, a potent, orally active peptidoleukotriene receptor antagonist, in guinea-pig. Pulm Pharmacol. 1991;4(3):177-89.
• [7] An update on the role of leukotrienes in asthma. Curr Opin Allergy Clin Immunol. 2010 February; 10(1): 60-66.
• [8] The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation. Arthritis Rheum. 1996 Mar;39(3):515-21.
• [9] Effects of NZ-107 on tracheal responses to adenosine in the guinea pig. Jpn J Pharmacol. 1991 May;56(1):79-84.
• [10] Effect of SMP-028 on steroidogenesis in rats; mechanism of toxicological events on endocrine organs of rats. Toxicol In Vitro. 2014 Apr;28(3):397-402.
• [11] In vitro pharmacology of ICI 198,615: a novel, potent and selective peptide leukotriene antagonist. J Pharmacol Exp Ther. 1987 Nov;243(2):548-56.
• [12] New drugs for asthma. Nat Rev Drug Discov. 2004 Oct;3(10):831-44.
• [13] Effect of 1,6-dihydro-2[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidineca rboxyli c acid on ethanol-induced microvascular injury in rats. Arzneimittelforschung. 1996 Aug;46(8):779-83.