General Information of Drug Therapeutic Target (DTT) (ID: TTTXQF6)

DTT Name RNA-binding protein Musashi-2 (MSI2)
Synonyms RNA-binding protein Musashi homolog 2; Musashi-2
Gene Name MSI2
DTT Type
Discontinued target
[1]
UniProt ID
MSI2H_HUMAN
TTD ID
T35817
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKR
SRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSAN
TVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMV
ECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQ
FPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYIS
AASPQPGSGFGHGIAGPLIATAFTNGYH
Function May play a role in the proliferation and maintenance of stem cells in the central nervous system. RNA binding protein that regulates the expression of target mRNAs at the translation level.
KEGG Pathway
mRNA surveillance pathway (hsa03015 )
Reactome Pathway
RHOBTB2 GTPase cycle (R-HSA-9013418 )

References

1 The Pluripotency Factor Musashi-2 Is a Novel Target for Lung Cancer Therapy.Ann Am Thorac Soc. 2018 Apr;15(Supplement_2):S124.