Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTU593I)

DTT Name	Neurokinin receptor (NKR)
Gene Name	NKR
DTT Type	Literature-reported target	[1]
UniProt ID	NOUNIPROTAC
TTD ID	T82514
Function	This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
KEGG Pathway	Calcium signaling pathway (hsa04020 ) Neuroactive ligand-receptor interaction (hsa04080 ) Measles (hsa05162 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NSL-036	DMPG703	Neuropathic pain	8E43.0	Terminated	[1]
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References

1	US patent application no. 2008,0039,404, Bifunctional analgesic compounds for opioid receptor agonists and neurokinin-1 receptor antagonists.