| DTT Name |
HUMAN dibasic-processing enzyme (Furin)
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| Synonyms |
Paired basic amino acid residuecleaving enzyme; Paired basic amino acid residue-cleaving enzyme; PCSK3; PACE; FUR; Dibasicprocessing enzyme |
| Gene Name |
FURIN
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| BioChemical Class |
Peptidase
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| UniProt ID |
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| TTD ID |
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| 3D Structure |
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| EC Number |
EC 3.4.21.75
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| Sequence |
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI
FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ
QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP
DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV
SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH
ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD
EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE
EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCL
SCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL
SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEG
RGERTAFIKDQSAL
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| Function |
Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. |
| KEGG Pathway |
- Viral life cycle - HIV-1 (hsa03250 )
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| Reactome Pathway |
- Collagen degradation (R-HSA-1442490 )
- Elastic fibre formation (R-HSA-1566948 )
- Activation of Matrix Metalloproteinases (R-HSA-1592389 )
- Removal of aminoterminal propeptides from gamma-carboxylated proteins (R-HSA-159782 )
- NGF processing (R-HSA-167060 )
- Synthesis and processing of ENV and VPU (R-HSA-171286 )
- Signaling by PDGF (R-HSA-186797 )
- Pre-NOTCH Processing in Golgi (R-HSA-1912420 )
- TGF-beta receptor signaling activates SMADs (R-HSA-2173789 )
- Uptake and function of anthrax toxins (R-HSA-5210891 )
- Formation of the cornified envelope (R-HSA-6809371 )
- Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889 )
- CD163 mediating an anti-inflammatory response (R-HSA-9662834 )
- Potential therapeutics for SARS (R-HSA-9679191 )
- Attachment and Entry (R-HSA-9694614 )
- Amyloid fiber formation (R-HSA-977225 )
- Signaling by NODAL (R-HSA-1181150 )
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