General Information of Drug Therapeutic Target (DTT) (ID: TTULOD8)

DTT Name Transcription factor E2-alpha (TCF3)
Synonyms
bHLHb21; Transcription factor ITF-1; Transcription factor 3; TCF-3; Kappa-E2-binding factor; Immunoglobulin transcription factor 1; Immunoglobulin enhancer-binding factor E12/E47; ITF1; E2A; Class B basic helix-loop-helix protein 21
Gene Name TCF3
DTT Type
Literature-reported target
[1]
UniProt ID
TFE2_HUMAN
TTD ID
T95715
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWG
SGDQSSSSFDPSRTFSEGTHFTESHSSLSSSTFLGPGLGGKSGERGAYASFGRDAGVGGL
TQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGL
PSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPML
GGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGAT
YGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSP
QGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLP
GHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPD
SYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSPDEDEDDLLPP
EQKAEREKERRVANNARERLRVRDINEAFKELGRMCQLHLNSEKPQTKLLILHQAVSVIL
NLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQMVLSAPHPGLSEAHNPAGHM
Function
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
KEGG Pathway
Signaling pathways regulating pluripotency of stem cells (hsa04550 )
Human T-cell leukemia virus 1 infection (hsa05166 )
Transcriptional misregulation in cancer (hsa05202 )
Reactome Pathway
RUNX1 regulates transcription of genes involved in differentiation of HSCs (R-HSA-8939236 )
Myogenesis (R-HSA-525793 )

References

1 Activating transcription factor 3 is a target molecule linking hepatic steatosis to impaired glucose homeostasis. J Hepatol. 2017 Aug;67(2):349-359.