Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTV1YFT)

DTT Name	Heparin binding protein (FGFBP1)
Synonyms	HBp17; HBP17 heparin-binding and FGF-binding protein; Fibroblast growth factor binding protein 1; FGFBP1; FGF-binding protein HBp17; FGF-BP
Gene Name	FGFBP1
DTT Type	Literature-reported target	[1]
BioChemical Class	Fibroblast growth factor-binding
UniProt ID	FGFP1_HUMAN
TTD ID	T43605
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MKICSLTLLSFLLLAAQVLLVEGKKKVKNGLHSKVVSEQKDTLGNTQIKQKSRPGNKGKF VTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAGNPTSCLKLKDERVYWKQVARNL RSQKDICRYSKTAVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKGKETT PSSLAVTQTMATKAPECVEDPDMANQRKTALEFCGETWSSLCTFFLSIVQDTSC
Function	Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
Reactome Pathway	FGFR2b ligand binding and activation (R-HSA-190377 )

References

1	Ribozyme-targeting of a secreted FGF-binding protein (FGF-BP) inhibits proliferation of prostate cancer cells in vitro and in vivo. Oncogene. 2002 Aug 22;21(37):5733-42.