Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTV1ZSQ)

DTT Name Adenylate cyclase type 1 (ADCY1)
Synonyms Ca(2+)/calmodulin-activated adenylyl cyclase; Adenylyl cyclase 1; Adenylate cyclase type I; ATP pyrophosphate-lyase 1
Gene Name ADCY1
DTT Type
Successful target
 [1]
Related Disease
Nutritional deficiency [ICD-11: 5B50-5B71]
BioChemical Class
Phosphorus-oxygen lyase
UniProt ID
ADCY1_HUMAN
TTD ID
T63609
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 4.6.1.1
Sequence
MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAA
TLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQ
QVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVR
SLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQR
KAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHD
NVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGL
TQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS
NDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSH
RRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALR
TASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQK
YHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRV
QCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTALP
TLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRTGGGAV
SGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNL
LPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEI
IADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFD
VLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQV
TEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQIRSLGLDRKMCPFGRA
GLQGRRPPVCPMPGVSVRAGLPPHSPGQYLPSAAAGKEA
Function
Mediates responses to increased cellular Ca(2+)/calmodulin levels. May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina. Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
KEGG Pathway
Purine metabolism (hsa00230 )
Rap1 signaling pathway (hsa04015 )
Calcium signaling pathway (hsa04020 )
cGMP-PKG signaling pathway (hsa04022 )
cAMP signaling pathway (hsa04024 )
Chemokine signaling pathway (hsa04062 )
Oocyte meiosis (hsa04114 )
Adrenergic signaling in cardiomyocytes (hsa04261 )
Vascular smooth muscle contraction (hsa04270 )
Gap junction (hsa04540 )
Platelet activation (hsa04611 )
Circadian entrainment (hsa04713 )
Long-term potentiation (hsa04720 )
Retrograde endocannabinoid signaling (hsa04723 )
Glutamatergic synapse (hsa04724 )
Cholinergic synapse (hsa04725 )
GABAergic synapse (hsa04727 )
Inflammatory mediator regulation of TRP channels (hsa04750 )
Insulin secretion (hsa04911 )
GnRH signaling pathway (hsa04912 )
Ovarian steroidogenesis (hsa04913 )
Progesterone-mediated oocyte maturation (hsa04914 )
Estrogen signaling pathway (hsa04915 )
Melanogenesis (hsa04916 )
Thyroid hormone synthesis (hsa04918 )
Oxytocin signaling pathway (hsa04921 )
Regulation of lipolysis in adipocytes (hsa04923 )
Salivary secretion (hsa04970 )
Gastric acid secretion (hsa04971 )
Pancreatic secretion (hsa04972 )
Bile secretion (hsa04976 )
Morphine addiction (hsa05032 )
Chagas disease (American trypanosomiasis) (hsa05142 )
Amoebiasis (hsa05146 )
HTLV-I infection (hsa05166 )
Pathways in cancer (hsa05200 )
Dilated cardiomyopathy (hsa05414 )
Reactome Pathway
PKA activation (R-HSA-163615 )
PKA activation in glucagon signalling (R-HSA-164378 )
G alpha (s) signalling events (R-HSA-418555 )
G alpha (i) signalling events (R-HSA-418594 )
G alpha (z) signalling events (R-HSA-418597 )
Vasopressin regulates renal water homeostasis via Aquaporins (R-HSA-432040 )
Hedgehog 'off' state (R-HSA-5610787 )
Glucagon signaling in metabolic regulation (R-HSA-163359 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Adenosine monophosphate DMNIJT0 Malnutrition 5B50-5B71 Approved [1]
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References

1 Ecto- and cytosolic 5'-nucleotidases in normal and AMP deaminase-deficient human skeletal muscle. Biol Chem. 2006 Jan;387(1):53-8.