Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTVF2BJ)

DTT Name Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)
Synonyms UNQ2510/PRO5998; Sialyltransferase 9; ST3Gal V; ST3GAL5; Ganglioside GM3 synthase; CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
Gene Name ST3GAL5
DTT Type
Literature-reported target
 [1]
BioChemical Class
Glycosyl transferase
UniProt ID
SIAT9_HUMAN
TTD ID
T37271
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
EC 2.4.99.9
Sequence
MRTKAAGCAERRPLQPRTEAAAAPAGRAMPSEYTYVKLRSDCSRPSLQWYTRAQSKMRRP
SLLLKDILKCTLLVFGVWILYILKLNYTTEECDMKKMHYVDPDHVKRAQKYAQQVLQKEC
RPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESKYDPPFGFRKFSSKVQTLLELLPE
HDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTI
RMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIP
LQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAG
FGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVVKDLSGGIDREF
Function Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide).
KEGG Pathway
Glycosphingolipid biosynthesis - ganglio series (hsa00604 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Sialic acid metabolism (R-HSA-4085001 )
BioCyc Pathway
MetaCyc:HS03904-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine DM6HGUL Discovery agent N.A. Investigative [1]
------------------------------------------------------------------------------------

References

1 S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.