| DTT Name |
HUMAN receptor-interacting protein 1 (RIPK1)
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| Synonyms |
Receptor-interacting serine/threonine-protein kinase 1; RIP1; RIP-1; RIP; Cell death protein RIP |
| Gene Name |
RIPK1
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| BioChemical Class |
Kinase
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| UniProt ID |
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| TTD ID |
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| 3D Structure |
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| EC Number |
EC 2.7.11.1
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| Sequence |
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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| Function |
Human protein receptor interacting serine/threonine kinase 1 interacts with SARS-CoV-2 Nsp12 protein with high significance, which indicates RIPK1 as a potential therapeutic target. |
| KEGG Pathway |
- NF-kappa B signaling pathway (hsa04064 )
- Apoptosis (hsa04210 )
- Necroptosis (hsa04217 )
- Toll-like receptor signaling pathway (hsa04620 )
- NOD-like receptor signaling pathway (hsa04621 )
- RIG-I-like receptor signaling pathway (hsa04622 )
- Cytosolic DNA-sensing pathway (hsa04623 )
- TNF signaling pathway (hsa04668 )
- Alcoholic liver disease (hsa04936 )
- Pathogenic Escherichia coli infection (hsa05130 )
- Shigellosis (hsa05131 )
- Salmonella infection (hsa05132 )
- Hepatitis C (hsa05160 )
- Human cytomegalovirus infection (hsa05163 )
- Epstein-Barr virus infection (hsa05169 )
- Human immunodeficiency virus 1 infection (hsa05170 )
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| Reactome Pathway |
- TICAM1, RIP1-mediated IKK complex recruitment (R-HSA-168927 )
- RIP-mediated NFkB activation via ZBP1 (R-HSA-1810476 )
- TRIF-mediated programmed cell death (R-HSA-2562578 )
- TRP channels (R-HSA-3295583 )
- Regulation by c-FLIP (R-HSA-3371378 )
- RIPK1-mediated regulated necrosis (R-HSA-5213460 )
- CASP8 activity is inhibited (R-HSA-5218900 )
- TNFR1-induced proapoptotic signaling (R-HSA-5357786 )
- Regulation of TNFR1 signaling (R-HSA-5357905 )
- TNFR1-induced NFkappaB signaling pathway (R-HSA-5357956 )
- Regulation of necroptotic cell death (R-HSA-5675482 )
- Ub-specific processing proteases (R-HSA-5689880 )
- Ovarian tumor domain proteases (R-HSA-5689896 )
- Dimerization of procaspase-8 (R-HSA-69416 )
- TNF signaling (R-HSA-75893 )
- TLR3-mediated TICAM1-dependent programmed cell death (R-HSA-9013957 )
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (R-HSA-933543 )
- IKK complex recruitment mediated by RIP1 (R-HSA-937041 )
- Potential therapeutics for SARS (R-HSA-9679191 )
- Microbial modulation of RIPK1-mediated regulated necrosis (R-HSA-9686347 )
- Defective RIPK1-mediated regulated necrosis (R-HSA-9693928 )
- Caspase activation via Death Receptors in the presence of ligand (R-HSA-140534 )
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