Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTVQJLY)

DTT Name Lipopolysaccharide-binding protein (LBP)
Synonyms LBP
Gene Name LBP
DTT Type
Literature-reported target
 [1]
BioChemical Class
Bactericidal permeability increasing protein
UniProt ID
LBP_HUMAN
TTD ID
T52110
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGALARALPSILLALLLTSTPEALGANPGLVARITDKGLQYAAQEGLLALQSELLRITLP
DFTGDLRIPHVGRGRYEFHSLNIHSCELLHSALRPVPGQGLSLSISDSSIRVQGRWKVRK
SFFKLQGSFDVSVKGISISVNLLLGSESSGRPTVTASSCSSDIADVEVDMSGDLGWLLNL
FHNQIESKFQKVLESRICEMIQKSVSSDLQPYLQTLPVTTEIDSFADIDYSLVEAPRATA
QMLEVMFKGEIFHRNHRSPVTLLAAVMSLPEEHNKMVYFAISDYVFNTASLVYHEEGYLN
FSITDDMIPPDSNIRLTTKSFRPFVPRLARLYPNMNLELQGSVPSAPLLNFSPGNLSVDP
YMEIDAFVLLPSSSKEPVFRLSVATNVSATLTFNTSKITGFLKPGKVKVELKESKVGLFN
AELLEALLNYYILNTFYPKFNDKLAEGFPLPLLKRVQLYDLGLQIHKDFLFLGANVQYMR
V
Function
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
KEGG Pathway
NF-kappa B signaling pathway (hsa04064 )
Toll-like receptor signaling pathway (hsa04620 )
Alcoholic liver disease (hsa04936 )
Tuberculosis (hsa05152 )
Lipid and atherosclerosis (hsa05417 )
Reactome Pathway
Transfer of LPS from LBP carrier to CD14 (R-HSA-166020 )
Regulation of TLR by endogenous ligand (R-HSA-5686938 )
Interleukin-4 and Interleukin-13 signaling (R-HSA-6785807 )
Toll Like Receptor 4 (TLR4) Cascade (R-HSA-166016 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
E-5531 DMBFYWU Sepsis 1G40-1G41 Discontinued in Phase 2 [2]
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References

1 Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88. J Immunol. 2003 Dec 1;171(11):6145-53.
2 The cellular Toll-like receptor 4 antagonist E5531 can act as an agonist in horse whole blood. Vet Immunol Immunopathol. 2007 Apr 15;116(3-4):182-9.