Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTVSEBF)

• DTT Name: Proteinase activated receptor 3 (F2RL2)
• Synonyms: Thrombin receptor-like 2; Protease activated receptor 3; PAR-3; F2RL2; Coagulation factor II receptor-like 2
• Gene Name: F2RL2
• DTT Type: Literature-reported target; [1]
• BioChemical Class: GPCR rhodopsin
• UniProt ID: PAR3_HUMAN
• TTD ID: T24542
• Sequence:
  MKALIFAAAGLLLLLPTFCQSGMENDTNNLAKPTLPIKTFRGAPPNSFEEFPFSALEGWT
  GATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLF
  FRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCS
  ILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQP
  DITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYV
  KASLLILVIFTICFAPSNIILIIHHANYYYNNTDGLYFIYLIALCLGSLNSCLDPFLYFL
  MSKTRNHSTAYLTK
• Function: Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
• KEGG Pathway:
  Neuroactive ligand-receptor interaction (hsa04080)
  Complement and coagulation cascades (hsa04610)
• Reactome Pathway:
  G alpha (q) signalling events (R-HSA-416476)
  Thrombin signalling through proteinase activated receptors (PARs) (R-HSA-456926)
  Peptide ligand-binding receptors (R-HSA-375276)

References

• [1] Protease-activated receptors: the role of cell-surface proteolysis in signalling. Essays Biochem. 2002;38:169-83.