Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTVSFJW)

• DTT Name: Calcitonin gene-related peptide 1 (CALCA)
• Synonyms: Calcitonin gene-related peptide I; CGRP-I; CALCA; CALC1; Alpha-type CGRP
• Gene Name: CALCA
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Cytotoxic amylin family
• UniProt ID: CALCA_HUMAN
• TTD ID: T93509
• Sequence:
  MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQ
  MKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFG
  RRRRDLQA
• Function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
• Reactome Pathway:
  Calcitonin-like ligand receptors (R-HSA-419812)
  G alpha (s) signalling events (R-HSA-418555)

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cizolirtine	DMOFTRE	Neuropathic pain	8E43.0	Phase 2	[1]

12 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ac-VTHRLAGLLSRSGGVVKNNFVPTDVGPFAF-NH2	DMO0W9V	Discovery agent	N.A.	Investigative	[2]
Ac-VTHRLAGLLSRSGGVVRKNFVPTDVGPFAF-NH2	DMWJ2M5	Discovery agent	N.A.	Investigative	[2]
Ac-WVEHRLKGELSRKGGVV[hArg]KNFVPTDVGPFAF-NH2	DM9W21L	Discovery agent	N.A.	Investigative	[2]
Ac-WVTHQLAGLLSQSGGVVRKNFVPTDVGPFAF-NH2	DM3BUP6	Discovery agent	N.A.	Investigative	[2]
Ac-WVTHRLAGLLSRSGGVVRKNFVPTDVGPFAF-NH2	DMSMVK4	Discovery agent	N.A.	Investigative	[2]
Ac-WVTHRLAGLLS[Cit]SGGVVRKNFVPTDVGPFAF-NH2	DMKO982	Discovery agent	N.A.	Investigative	[2]
Ac-WVTH[Cit]LAGLLSRSGGVVRKNFVPTDVGPFAF-NH2	DMR1N53	Discovery agent	N.A.	Investigative	[2]
Ac-WVTH[Cit]LAGLLS[Cit]SGGVVRKNFVPTDVGPFAF-NH2	DMJU4AM	Discovery agent	N.A.	Investigative	[2]
Ac-WVTH[hArg]LAGLLS[hArg]SGGVVRKNFVPTDVGPFAF-NH2	DM19NMF	Discovery agent	N.A.	Investigative	[2]
FV-Aib-TDVGPFAF	DMEI890	Discovery agent	N.A.	Investigative	[2]
VTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2	DMJ2PG1	Discovery agent	N.A.	Investigative	[2]
WVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2	DMVZB8U	Discovery agent	N.A.	Investigative	[2]

Molecular Expression Atlas (MEA) of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Asthma	CA23	Nasal and bronchial airway	1.80E-07	-0.32	-0.62

References

• [1] Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
• [2] Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97.