Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTW14O3)

DTT Name	Programmed cell death 1 ligand 2 (PD-L2)
Synonyms	Programmed death ligand 2; PDL2; PDCD1L2; PDCD1 ligand 2; PD-1 ligand 2; CD273; Butyrophilin B7-DC; B7DC; B7-DC
Gene Name	PDCD1LG2
DTT Type	Patented-recorded target	[1]
BioChemical Class	Immunoglobulin
UniProt ID	PD1L2_HUMAN
TTD ID	T50035
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MIFLLLMLSLELQLHQIAALFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQ KVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVK ASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVL RLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPTWLLHIFIPFCIIAFIFIATV IALRKQLCQKLYSSKDTTKRPVTTTKREVNSAI
Function	Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner.
KEGG Pathway	Cell adhesion molecules (CAMs) (hsa04514 )
Reactome Pathway	PD-1 signaling (R-HSA-389948 )

References

1	PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2001 Mar;2(3):261-8.