General Information of Drug Therapeutic Target (DTT) (ID: TTW4Y2M)

DTT Name cAMP protein kinase type II-beta (PRKAR2B)
Synonyms cAMP-dependent protein kinase type II-beta regulatory subunit; Type RIIbeta regulatory subunit of protein kinase A; RIIbeta subunit of cAMP-dependent protein kinase; PKA RIIbeta-subunit
Gene Name PRKAR2B
DTT Type
Literature-reported target
[1]
BioChemical Class
Kinase
UniProt ID
KAP3_HUMAN
TTD ID
T74952
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGD
LGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAY
NPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEH
VIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATS
PGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDG
EQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKP
RAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA
Function
Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
KEGG Pathway
Apoptosis (hsa04210 )
Insulin signaling pathway (hsa04910 )
Reactome Pathway
PKA activation in glucagon signalling (R-HSA-164378 )
DARPP-32 events (R-HSA-180024 )
Regulation of PLK1 Activity at G2/M Transition (R-HSA-2565942 )
Loss of Nlp from mitotic centrosomes (R-HSA-380259 )
Recruitment of mitotic centrosome proteins and complexes (R-HSA-380270 )
Loss of proteins required for interphase microtubule organization?from the centrosome (R-HSA-380284 )
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (R-HSA-381676 )
Vasopressin regulates renal water homeostasis via Aquaporins (R-HSA-432040 )
Hedgehog 'off' state (R-HSA-5610787 )
Anchoring of the basal body to the plasma membrane (R-HSA-5620912 )
Factors involved in megakaryocyte development and platelet production (R-HSA-983231 )
PKA activation (R-HSA-163615 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
BALANOL DMDLN9E N. A. N. A. Terminated [1]
------------------------------------------------------------------------------------
16 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X Discovery agent N.A. Investigative [2]
AdcAhxArg4Lys(biotin)-PEG-OMe DMZYJHV Discovery agent N.A. Investigative [3]
AdcAhxArg4Lys-PEGOMe DMQ2C8X Discovery agent N.A. Investigative [3]
AdcAhxArg4NH(CH2)6NH2 DMSYMRJ Discovery agent N.A. Investigative [3]
AdcAhxArg6 DM7J3K0 Discovery agent N.A. Investigative [3]
AdoC(Ahx)Arg6 DMW5HO0 Discovery agent N.A. Investigative [4]
AdoC(Aoc)Arg6 DMRSCO2 Discovery agent N.A. Investigative [4]
AdoC(Aun)Arg6 DMDLHAB Discovery agent N.A. Investigative [4]
AdoC(beta-Ala)2AlaArg6 DMPUAFC Discovery agent N.A. Investigative [4]
AdoC(beta-Ala)Arg6 DMO8D4V Discovery agent N.A. Investigative [4]
AdoC(betaAsp)2AlaArg6 DM65B7Y Discovery agent N.A. Investigative [4]
AdoC(Dpr)2AlaArg6 DM2TWSZ Discovery agent N.A. Investigative [4]
AdoC(GABA)Arg6 DMMWNPT Discovery agent N.A. Investigative [4]
AdoCGlyArg6 DMVQJP0 Discovery agent N.A. Investigative [4]
Ro-4396686 DM5DMCH Discovery agent N.A. Investigative [5]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [6]
------------------------------------------------------------------------------------
⏷ Show the Full List of 16 Investigative Drug(s)

References

1 Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. J Med Chem. 2005 Sep 8;48(18):5613-38. Address;
2 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9.
3 Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.
4 Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.
5 Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3.
6 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.