Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTWDM4U)

• DTT Name: HUMAN ATPase H+ transporting accessory protein 1 (ATP6AP1)
• Synonyms: V-type proton ATPase subunit S1; V-ATPase subunit S1; V-ATPase S1 accessory protein; V-ATPase Ac45 subunit; Vacuolar proton pump subunit S1; Protein XAP-3
• Gene Name: ATP6AP1
• BioChemical Class: Vacuolar ATPase subunit S1 family
• UniProt ID: VAS1_HUMAN
• TTD ID: T01211
• Sequence:
  MMAAMATARVRMGPRCAQALWRMPWLPVFLSLAAAAAAAAAEQQVPLVLWSSDRDLWAPA
  ADTHEGHITSDLQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNL
  ENALDLAPSSLVLPAVDWYAVSTLTTYLQEKLGASPLHVDLATLRELKLNASLPALLLIR
  LPYTASSGLMAPREVLTGNDEVIGQVLSTLKSEDVPYTAALTAVRPSRVARDVAVVAGGL
  GRQLLQKQPVSPVIHPPVSYNDTAPRILFWAQNFSVAYKDQWEDLTPLTFGVQELNLTGS
  FWNDSFARLSLTYERLFGTTVTFKFILANRLYPVSARHWFTMERLEVHSNGSVAYFNASQ
  VTGPSIYSFHCEYVSSLSKKGSLLVARTQPSPWQMMLQDFQIQAFNVMGEQFSYASDCAS
  FFSPGIWMGLLTSLFMLFIFTYGLHMILSLKTMDRFDDHKGPTISLTQIV
• Function: Human protein ATPase H+ transporting accessory protein 1 interacts with SARS-CoV-2 Nsp6 protein with high significance, which indicates ATP6AP1 as a potential therapeutic target.
• KEGG Pathway:
  Oxidative phosphorylation (hsa00190)
  Metabolic pathways (hsa01100)
  Lysosome (hsa04142)
  Phagosome (hsa04145)
  Vibrio cholerae infection (hsa05110)
  Epithelial cell signaling in Helicobacter pylori infection (hsa05120)
  Tuberculosis (hsa05152)
  Hepatitis B (hsa05161)
  Human papillomavirus infection (hsa05165)
  Rheumatoid arthritis (hsa05323)
• Reactome Pathway:
  RHOA GTPase cycle (R-HSA-8980692)
  Transferrin endocytosis and recycling (R-HSA-917977)
  Ion channel transport (R-HSA-983712)
  Insulin receptor recycling (R-HSA-77387)
• BioCyc Pathway: MetaCyc:HS01034-MON

References

• [1] A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature. 2020 Apr 30. doi: 10.1038/s41586-020-2286-9.