Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTWR48J)

DTT Name	Caspase-5 (CASP5)
Synonyms	Protease TY; Protease ICH-3; ICH3; ICE(rel)-III; CASP-5
Gene Name	CASP5
DTT Type	Patented-recorded target	[1]
BioChemical Class	Peptidase
UniProt ID	CASP5_HUMAN
TTD ID	T89565
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 3.4.22.58
Sequence	MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE RATLTRDFYLFPGN
Function	During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation. Mediator of programmed cell death (apoptosis).
KEGG Pathway	NOD-like receptor signaling pathway (hsa04621 ) Salmonella infection (hsa05132 )
Reactome Pathway	Pyroptosis (R-HSA-5620971 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
M826	DM9NPE4	Discovery agent	N.A.	Investigative	[2]
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References

1	Caspase inhibitors: a review of recently patented compounds (2013-2015).Expert Opin Ther Pat. 2018 Jan;28(1):47-59.
2	Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80.