Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTWT5K7)

• DTT Name: 5-HT 1 receptor (5HT1R)
• Synonyms: Serotonin receptor 1; 5-hydroxytryptamine receptor 1; 5-HT1 receptor
• Gene Name: NO-GeName
• DTT Type: Patented-recorded target; [1]
• Related Disease:
  Anxiety disorder [ICD-11: 6B00-6B0Z]
  Depression [ICD-11: 6A70-6A7Z]
  Migraine [ICD-11: 8A80]
• BioChemical Class: GPCR rhodopsin
• UniProt ID: NOUNIPROTAC
• TTD ID: T67054

Molecular Interaction Atlas (MIA) of This DTT

3 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aryl piperazine derivative 14	DMY8NEL	N. A.	N. A.	Patented	[1]
Aryl piperazine derivative 15	DMRK4IE	N. A.	N. A.	Patented	[1]
Aryl piperazine derivative 16	DM63XHT	N. A.	N. A.	Patented	[1]

4 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Befiperide	DMGAPH1	Anxiety disorder	6B00-6B0Z	Terminated	[2]
FCE-25876	DMR3ZWA	Major depressive disorder	6A70.3	Terminated	[3]
RU 24969	DMVW3I9	N. A.	N. A.	Terminated	[4]
SRSS-023	DMUGPDB	Migraine	8A80	Terminated	[5]

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyanopindolol	DMIBLGH	Discovery agent	N.A.	Investigative	[6]

References

• [1] 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689.
• [2] Behavioral Pharmacology of 5-ht. Paul Bevan, Paul Bevan Duphar, Alexander R. Cools. 2013. Figure(15.2).
• [3] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001389)
• [4] Effect of chronic treatment with 5-HT1 agonist (8-OH-DPAT and RU 24969) and antagonist (isapirone) drugs on the behavioural responses of mice to 5-HT1 and 5-HT2 agonists. Br J Pharmacol. 1986 Oct;89(2):377-84.
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019089)
• [6] The inhibitory effect of serotonin on the spontaneous discharge of suprachiasmatic neurons in hypothalamic slice is mediated by 5-HT(7) receptor. Brain Res Bull. 2001 Mar 1;54(4):395-8.