Details of the Drug Therapeutic Target (DTT) | DrugMAP

General Information of Drug Therapeutic Target (DTT) (ID: TTWVJU1)

DTT Name	Urea transporter 1 (SLC14A1)
Synonyms	Urea transporter, erythrocyte; UTE; UT1; Solute carrier family 14 member 1; RACH1; JK; HUT11
Gene Name	SLC14A1
DTT Type	Literature-reported target				[1]
BioChemical Class	Urea transporter family
UniProt ID	UT1_HUMAN
TTD ID	T92794
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFID WILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASG LYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPF NMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPW TGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGM FMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIY KMPLSKVTYPEENRIFYLQAKKRMVESPL
Function	Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.
Reactome Pathway	Transport of bile salts and organic acids, metal ions and amine compounds (R-HSA-425366 )

The Drug Transporter (DTP) Role of This DTT

DTT DTP Name

Urea transporter 1 (SLC14A1) DTP Info

Gene Name

SLC14A1

2 Investigative Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
methylurea	DMAEQB6	Discovery agent	N.A.	Investigative	[2]
Thiourea	DMUELHN	N. A.	N. A.	Investigative	[3]
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References

1	Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1. J Med Chem. 2018 Apr 12;61(7):3209-3217.
2	Comparative transport efficiencies of urea analogues through urea transporter UT-B. Biochim Biophys Acta. 2007 Jul;1768(7):1815-21.
3	Functional differentiation of the human red blood cell and kidney urea transporters. Am J Physiol. 1996 Dec;271(6 Pt 2):F1264-8.