Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTWY768)

DTT Name	ZW10 interactor (ZWINT)
Synonyms	Zwint-1; ZW10-interacting protein 1
Gene Name	ZWINT
DTT Type	Literature-reported target	[1]
UniProt ID	ZWINT_HUMAN
TTD ID	T95621
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MEAAETEAEAAALEVLAEVAGILEPVGLQEEAELPAKILVEFVVDSQKKDKLLCSQLQVA DFLQNILAQEDTAKGLDPLASEDTSRQKAIAAKEQWKELKATYREHVEAIKIGLTKALTQ MEEAQRKRTQLREAFEQLQAKKQMAMEKRRAVQNQWQLQQEKHLQHLAEVSAEVRERKTG TQQELDRVFQKLGNLKQQAEQERDKLQRYQTFLQLLYTLQGKLLFPEAEAEAENLPDDKP QQPTRPQEQSTGDTMGRDPGVSFKAVGLQPAGDVNLP
Function	Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.
Reactome Pathway	Separation of Sister Chromatids (R-HSA-2467813 ) Resolution of Sister Chromatid Cohesion (R-HSA-2500257 ) RHO GTPases Activate Formins (R-HSA-5663220 ) Mitotic Prometaphase (R-HSA-68877 ) EML4 and NUDC in mitotic spindle formation (R-HSA-9648025 ) Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444 )

References

1	Decreased Expression of ZWINT is Associated With Poor Prognosis in Patients With HCC After Surgery. Technol Cancer Res Treat. 2018 Jan 1;17:1533033818794190.