General Information of Drug Therapeutic Target (DTT) (ID: TTX2DRI)

DTT Name Activin receptor type IIA (ACVR2A)
Synonyms Activin receptor type2A; Activin receptor type-2A; ACVR2; ACTRIIA; ACTR-IIA
Gene Name ACVR2A
DTT Type
Clinical trial target
[1]
BioChemical Class
Kinase
UniProt ID
AVR2A_HUMAN
TTD ID
T47366
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.7.11.30
Sequence
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC
FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM
EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV
GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG
QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT
QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
Function
Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.
KEGG Pathway
Cytokine-cytokine receptor interaction (hsa04060 )
TGF-beta signaling pathway (hsa04350 )
Signaling pathways regulating pluripotency of stem cells (hsa04550 )
Fluid shear stress and atherosclerosis (hsa05418 )
Reactome Pathway
Regulation of signaling by NODAL (R-HSA-1433617 )
Signaling by Activin (R-HSA-1502540 )
Signaling by BMP (R-HSA-201451 )
Signaling by NODAL (R-HSA-1181150 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
BYM338 DM1ARHT Inclusion body myositis 4A41.2 Phase 3 [1]
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References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)