Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTX5HEK)

• DTT Name: Caspase-10 (CASP10)
• Synonyms: MCH4; ICE-like apoptotic protease 4; FLICE2; FAS-associated death domain protein interleukin-1B-converting enzyme 2; Caspase-10 subunit p23/17; Caspase-10 subunit p12; CASP-10; Apoptotic protease Mch-4
• Gene Name: CASP10
• DTT Type: Patented-recorded target; [1]
• BioChemical Class: Peptidase
• UniProt ID: CASPA_HUMAN
• TTD ID: T14894
• EC Number: EC 3.4.22.63
• Sequence:
  MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD
  VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY
  ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK
  LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN
  GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR
  QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR
  FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE
  QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKT
  MEIRGRKRTVWGAKQISATSLPTAISAQTPRPPMRRWSSVS
• Function: Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Involved in the activation cascade of caspases responsible for apoptosis execution.
• KEGG Pathway:
  Apoptosis (hsa04210)
  RIG-I-like receptor signaling pathway (hsa04622)
  TNF signaling pathway (hsa04668)
  Tuberculosis (hsa05152)
  Hepatitis B (hsa05161)
• Reactome Pathway:
  FasL/ CD95L signaling (R-HSA-75157)
  TRAIL signaling (R-HSA-75158)
  NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (R-HSA-933543)
  TP53 Regulates Transcription of Caspase Activators and Caspases (R-HSA-6803207)

References

• [1] Caspase inhibitors: a review of recently patented compounds (2013-2015).Expert Opin Ther Pat. 2018 Jan;28(1):47-59.