Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTXGTZU)

DTT Name Cardiotrophin-1 (CTF1)
Synonyms CTF1; CT-1
Gene Name CTF1
DTT Type
Clinical trial target
 [1]
BioChemical Class
Cytokine: interleukin
UniProt ID
CTF1_HUMAN
TTD ID
T94977
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRREGSLEDPQTDSSVSLLPHLEAKIRQTHSLAHLLTKYAEQLLQEYVQLQGDPFGLPS
FSPPRLPVAGLSAPAPSHAGLPVHERLRLDAAALAALPPLLDAVCRRQAELNPRAPRLLR
RLEDAARQARALGAAVEALLAALGAANRGPRAEPPAATASAASATGVFPAKVLGLRVCGL
YREWLSRTEGDLGQLLPGGSA
Function Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
KEGG Pathway
Cytokine-cytokine receptor interaction (hsa04060 )
Jak-STAT signaling pathway (hsa04630 )
Reactome Pathway
IL-6-type cytokine receptor ligand interactions (R-HSA-6788467 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cardiotrophin-1 DM5WKU1 Acute liver failure DB91 Phase 1 [1]
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Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Liver failure DD91.0 Liver tissue 1.16E-01 0.22 0.56
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References

1 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.