Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTXHSZK)

• DTT Name: Transcription factor SOX-5 (SOX5)
• Synonyms: SRY-box 5; LAMSHF; L-SOX5F; L-SOX5B; L-SOX5
• Gene Name: SOX5
• DTT Type: Literature-reported target; [1]
• UniProt ID: SOX5_HUMAN
• TTD ID: T49085
• Sequence:
  MLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPN
  KPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQS
  GESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAM
  GSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMEL
  AKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLL
  PPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGI
  PQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPAL
  RINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGK
  VAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSES
  RIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNL
  EKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYF
  NVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEP
  HIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN
• Function: Activates transcription of COL2A1 and AGC1 in vitro. Binds specifically to the DNA sequence 5'-AACAAT-3'.

References

• [1] Sox5 contributes to prostate cancer metastasis and is a master regulator of TGF--induced epithelial mesenchymal transition through controlling Twi... Br J Cancer. 2018 Jan;118(1):88-97.