Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTXI3KF)

DTT Name Pyridoxal kinase (PDXK)
Synonyms Pyridoxine kinase; PDXK
Gene Name PDXK
DTT Type
Literature-reported target
 [1]
BioChemical Class
Kinase
UniProt ID
PDXK_HUMAN
TTD ID
T76522
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.7.1.35
Sequence
MEEECRVLSIQSHVIRGYVGNRAATFPLQVLGFEIDAVNSVQFSNHTGYAHWKGQVLNSD
ELQELYEGLRLNNMNKYDYVLTGYTRDKSFLAMVVDIVQELKQQNPRLVYVCDPVLGDKW
DGEGSMYVPEDLLPVYKEKVVPLADIITPNQFEAELLSGRKIHSQEEALRVMDMLHSMGP
DTVVITSSDLPSPQGSNYLIVLGSQRRRNPAGSVVMERIRMDIRKVDAVFVGTGDLFAAM
LLAWTHKHPNNLKVACEKTVSTLHHVLQRTIQCAKAQAGEGVRPSPMQLELRMVQSKRDI
EDPEIVVQATVL
Function Required for synthesisof pyridoxal-5-phosphate from vitamin B6.
KEGG Pathway
( )
( )
Reactome Pathway
Vitamins B6 activation to pyridoxal phosphate (R-HSA-964975 )
Neutrophil degranulation (R-HSA-6798695 )
BioCyc Pathway
MetaCyc:HS08466-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-betagamma-meATP DMTNQCE Discovery agent N.A. Investigative [1]
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References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.