General Information of Drug Therapeutic Target (DTT) (ID: TTXJ3W7)

DTT Name PTEN messenger RNA (PTEN mRNA)
Synonyms
TEP1 (mRNA); Phosphatidylinositol 3,4,5trisphosphate 3phosphatase and dualspecificity protein phosphatase PTEN (mRNA); Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (mRNA); Mutated in multiple advanced cancers 1 (mRNA); MMAC1 (mRNA)
Gene Name PTEN
DTT Type
Literature-reported target
[1]
BioChemical Class
mRNA target
UniProt ID
PTEN_HUMAN
TTD ID
T03551
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 3.1.3.16
Sequence
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
Function
Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. Tumor suppressor.
KEGG Pathway
Inositol phosphate metabolism (hsa00562 )
Metabolic pathways (hsa01100 )
EGFR tyrosine kinase inhibitor resistance (hsa01521 )
FoxO signaling pathway (hsa04068 )
Phosphatidylinositol signaling system (hsa04070 )
Sphingolipid signaling pathway (hsa04071 )
p53 signaling pathway (hsa04115 )
Autophagy - animal (hsa04140 )
mTOR signaling pathway (hsa04150 )
PI3K-Akt signaling pathway (hsa04151 )
Cellular senescence (hsa04218 )
Focal adhesion (hsa04510 )
Insulin resistance (hsa04931 )
Human papillomavirus infection (hsa05165 )
Human T-cell leukemia virus 1 infection (hsa05166 )
Pathways in cancer (hsa05200 )
MicroRNAs in cancer (hsa05206 )
Chemical carcinogenesis - reactive oxygen species (hsa05208 )
Endometrial cancer (hsa05213 )
Glioma (hsa05214 )
Prostate cancer (hsa05215 )
Melanoma (hsa05218 )
Small cell lung cancer (hsa05222 )
Breast cancer (hsa05224 )
Hepatocellular carcinoma (hsa05225 )
Central carbon metabolism in cancer (hsa05230 )
PD-L1 expression and PD-1 checkpoint pathway in cancer (hsa05235 )
Diabetic cardiomyopathy (hsa05415 )
Reactome Pathway
Synthesis of IP3 and IP4 in the cytosol (R-HSA-1855204 )
Negative regulation of the PI3K/AKT network (R-HSA-199418 )
Downstream TCR signaling (R-HSA-202424 )
TP53 Regulates Metabolic Genes (R-HSA-5628897 )
PTEN Loss of Function in Cancer (R-HSA-5674404 )
Ub-specific processing proteases (R-HSA-5689880 )
Ovarian tumor domain proteases (R-HSA-5689896 )
Regulation of PTEN mRNA translation (R-HSA-8943723 )
Regulation of PTEN localization (R-HSA-8948747 )
Regulation of PTEN stability and activity (R-HSA-8948751 )
Transcriptional Regulation by MECP2 (R-HSA-8986944 )
Synthesis of PIPs at the plasma membrane (R-HSA-1660499 )
BioCyc Pathway
MetaCyc:HS10404-MON

References

1 Effect of triptolide on human oral cancer cell proliferation and PTEN gene mRNA expression in oral cancer. Zhonghua Kou Qiang Yi Xue Za Zhi. 2017 Jan 9;52(1):44-47.