Details of the Drug Therapeutic Target (DTT)
General Information of Drug Therapeutic Target (DTT) (ID: TTXJEOF)
| DTT Name | Ubiquitin-protein ligase E2 (UBE2E2) | ||||
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| Synonyms | Ubiquitin-conjugating enzyme E2 E2; Ubiquitin carrier protein E2; UbcH8; E2 ubiquitin-conjugating enzyme E2 | ||||
| Gene Name | UBE2E2 | ||||
| DTT Type |
Literature-reported target
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[1] | |||
| BioChemical Class |
Ubiquitin-conjugating enzyme
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| UniProt ID | |||||
| TTD ID | |||||
| 3D Structure | |||||
| EC Number |
EC 2.3.2.23
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| Sequence |
MSTEAQRVDDSPSTSGGSSDGDQRESVQQEPEREQVQPKKKEGKISSKTAAKLSTSAKRI
QKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSPDYPFKPPK VTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQ YMTNRAEHDRMARQWTKRYAT |
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| Function |
In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
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| KEGG Pathway | |||||
| Reactome Pathway | |||||